The anti-proliferation and anti-migration dual effects of aloe-emodin on KB cells and its mechanism / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 50-52, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-346774
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anti-proliferation and anti-migration dual effects of aloe-emodin on KB cells and its mechanisms.</p><p><b>METHODS</b>KB cells were treated with 2.5, 5, 10, 20 and 40 micromol/L aloe-emodin. Crystal violet assay was used to determine the long-term growth inhibition of aloe-emodin on human oral cancer KB cells. Scratch wound-healing motility assay was used to measure the antimigration effect The protein kinase C alpha and c-myc expression changes in protein levels were detected by Western blotting.</p><p><b>RESULTS</b>A durable cell growth inhibitory effect of aloe-emodin on KB cells was found. Treatment of aloe-emodin resulted in the inhibition of cell migration. The protein kinase C alpha and c-myc in protein levels were decreased upon treatment with aloe-emodin compared with controls.</p><p><b>CONCLUSIONS</b>The anti-proliferation and anti-migration effects of aloe-emodin on KB cells are associated with the suppression of protein kinase C pathway.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Protein Kinase C
/
KB Cells
/
Cell Movement
/
Genes, myc
/
Anthraquinones
/
Cell Proliferation
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Stomatology
Year:
2009
Type:
Article
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