Roles of matrix metalloproteinases and tissue specific inhibitors of metalloproteinases in dentinogenic ghost cell tumor and ghost cell odontogenic carcinoma / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 756-760, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-346791
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the roles of matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC).</p><p><b>METHODS</b>The expressions of MMP-2, MMP-9, MMP-14, TIMP-1 and TIMP-2 were examined in 15 DGCT cases and 9 GCOC cases by immunohistochemistry. Their mRNA expression in one DGCT case and one GCOC case were investigated by RT-PCT.MMP-2 and MMP-9 protein activities in the two cases were analyzed by gelatin zymography.</p><p><b>RESULTS</b>MMP-9 and TIMP-1 expressions elevated greatly in GCOC, and there was a significant difference (P < 0.05) in TIMP-1 expression between GCOC and DGCT.Pro-MMP-9, MMP-9 activated form, pro-MMP-2, and MMP-2 activated forms were detected in the GCOC case, while pro-MMP-9 and MMP-9 activated form were very faint in the DGCT case. The mRNA level of MMP-9 elevated obviously in the GCOC case, which was similar to that of TIMP-1.</p><p><b>CONCLUSIONS</b>The elevated expression of MMP-9 and TIMP-1 may influence the behaviour of GCOC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Mandibular Neoplasms
/
Odontogenic Tumors
/
Tissue Inhibitor of Metalloproteinases
/
Matrix Metalloproteinases
/
Dentin
/
Metabolism
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Stomatology
Year:
2008
Type:
Article
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