Chemical constituents of Periploca forrestii and their cytotoxicity activity / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3214-3216, 2009.
Article
in English
| WPRIM
| ID: wpr-346914
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of the roots of Periploca forrestii and evaluate their cytotoxicity activities.</p><p><b>METHOD</b>Silica gel column chromatography was employed for the isolation and purification of chemical constituents. The structures were identified on the basis of spectral data and the cytotoxicities of compounds 2-4 were investigated by several tumors cell lines including blood tumor (HL-60, CCRT-CEM), prostate tumor (PC-3, DU-145) and Melanoma (UACC-62).</p><p><b>RESULT</b>Four compounds were isolated and identified as follows, lupeol-20(29)-en-3-nonadecanoate (1), peroiforoside I (2), 3beta,5beta,14beta-3OH-8beta-H-car-20(22)-enolide (3), perplocin (4).</p><p><b>CONCLUSION</b>Compound 1 is a new lupane triterpene fatty acid ester. Compounds 2-4 showed notable cytotoxicity against all tumor lines.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Triterpenes
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Cell Survival
/
Chemistry
/
Plant Roots
/
HL-60 Cells
/
Inhibitory Concentration 50
/
Periploca
Limits:
Humans
Language:
English
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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