Optimization of cataplasm matrix with face-centered design-response surface method / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3211-3213, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-346915
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the matrix formulation of cataplasm.</p><p><b>METHOD</b>Face-centered design was used in the experimental design, and response surface was produced in quadratic polynomial after data fitting in order to explore the impacts of Sodium Polyacrylate, Carbomer and the cross-linking agent on stickiness of cataplasm, optimize the prescription of the cataplasm matrix and perform the evaluation analysis.</p><p><b>RESULT</b>The multiple correlation coefficient (R2) and adjusted R2 in the fitting method using quadratic polynomial were 0.970 and 0. 952 (F = 53.953, P = 0.0001), respectively, and the model was significant different. The ratio of optimum proportion of Sodium Polyacrylate, Carbomer and the cross-linking agent in the matrix of cataplasm was determined, which was proved efficaciously.</p><p><b>CONCLUSION</b>Face-centered design-response surface method is a simple method with good prediction result for the optimization of cataplasm matrix.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Chemistry
/
Chemistry, Pharmaceutical
/
Methods
/
Models, Theoretical
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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