Corneal penetration of PAMAM dendrimers-coated puerarin liposomes / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 30-34, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-346952
ABSTRACT
<p><b>OBJECTIVE</b>To study the corneal penetration of PAMAM dendrimers-coated puerarin liposomes in rabbits.</p><p><b>METHOD</b>Evaluated PAMAM (G2, G3) dendrimers-coated puerarin liposomes were prepared and the in vitro transcorneal penetration were compared to puerarin drop solution and uncoated liposomes. The effect of different proportion of PAMAM to phospholipids in formulation on corneal penetration and the penetration parameters were investigated.</p><p><b>RESULT</b>The steady state fluxes and permeability coefficients of puerarin by PAMAM G2 (1.0%) and PAMAM G3 (0.5%) coated puerarin liposomes were greater than that by puerarin drop solution and uncoated liposomess (P < 0.01), meanwhile the PAMAM G2 (1.0%) and PAMAM G3 (0.5%) coated liposomes were better than other ratios of coated liposomes for improvement of corneal penetration (P < 0.01).</p><p><b>CONCLUSION</b>The PAMAM coated liposomes is able to enhance the corneal penetration of puerarin and promising as an ocular drug carriers.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
In Vitro Techniques
/
Chemistry
/
Cornea
/
Dendrimers
/
Isoflavones
/
Liposomes
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Type:
Article
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