Application of collagen hydrogel in cartilage tissue engineering / 中国骨伤

ABSTRACT

Articular osteocartilage injury caused by trauma or bone disease is very common in clinical practices,the proportion of cartilage defects reached 40.31%. As the low self healing abilities of articular cartilage, the technology of tissue engineering becomes a new method to treat articular cartilage injuries with regenerative medicine. Scaffolds can be divided into preformed and hydrogel scaffolds according to properties. The traditional graft of pre-formed scaffold will bring the secondary injury to the cartilage around the defect, and the loose graft intergration with the defect surface is still a problem. Repairing irregular articular cartilage defects with ideal biomimic materials on the basis of avoiding secondary damage will become a main issue. The method of minimally invasive injecting, biomimics, and in situ remodeling brings hope to articular cartilage repairing. Below is a summary of the international and domestics reference data of recent years on collagen hydrogel in cartilage tissue engineering.