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Relaxant effects of Aike Mixture on isolated bladder and prostatic urethral smooth muscle of rabbits / 中国结合医学杂志
Chinese journal of integrative medicine ; (12): 420-424, 2014.
Article in English | WPRIM | ID: wpr-347180
ABSTRACT
<p><b>OBJECTIVE</b>To observe the relaxant effect of Aike Mixture (AKM) on isolated bladder and prostatic urethral smooth muscle of rabbits.</p><p><b>METHODS</b>The isolated bladder and prostatic urethral smooth muscle from male rabbits were placed in a Magnus bath and smooth muscle contraction was measured using a biological signal acquisition and analysis system. The effects of AKM in combination with methoxyamine, carbachol and CaCl2 on the contractile tension of muscle strips were determined by cumulative dosing.</p><p><b>RESULTS</b>AKM dose-dependently reduced contractile tension of bladder trigone smooth muscle (r=0.831, P<0.05), reduced contractile wave amplitude (r=0.837, P<0.05) and decreased contractile frequency (r=-0.917, P<0.01). AKM significantly inhibited the increases in smooth muscle contraction induced by methoxyamine, carbachol and CaCl2.</p><p><b>CONCLUSION</b>AKM dose-dependently inhibited the contraction of rabbit isolated bladder and prostatic urethral smooth muscle by antagonizing α1-adrenergic receptors and M-cholinergic receptors.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Prostate / Urethra / Urinary Bladder / In Vitro Techniques / Calcium Chloride / Carbachol / Drugs, Chinese Herbal / Receptors, Muscarinic Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Prostate / Urethra / Urinary Bladder / In Vitro Techniques / Calcium Chloride / Carbachol / Drugs, Chinese Herbal / Receptors, Muscarinic Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2014 Type: Article