Influence of super high molecular weight poly D,L-lactic acid on viability and new bone formation of osteoblasts / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 67-69, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-347302
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of the viability and new bone formation of osteoblasts by the super high molecular weight poly D,L-lactic acid (SHMW-PDLLA).</p><p><b>METHODS</b>1. The osteoblasts derived from neonatal rat were grown and maintained at steep of SHMW-PDLLA and normal culture medium. The viability and function of the osteoblasts were measured with MTT array. 2. The plate and screws made of SHMW-PDLLA were implanted and fixed at the artificial fractured mandible of dogs. Specimens were gained at 3 and 6 months and examined with macroscopy and SEM.</p><p><b>RESULTS</b>1. There is no significant difference of OD values between the experimental group and the control group (P > 0.05). The SHMW-PDLLA isn't toxic to osteoblast at 1 week and 2 weeks, and the toxicity is 3% at 3 days. 2. There were a lot of new bone formed between the implanted SHMW-PDLLA plate and bone tissues under SEM.</p><p><b>CONCLUSION</b>SHMW-PDLLA hasn't pathological influence on the viability and new bone formation of osteoblasts and it is feasible in tissue engineering of bone.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Osteogenesis
/
Pharmacology
/
Polyesters
/
Polymers
/
General Surgery
/
Bone Plates
/
Bone Screws
/
Microscopy, Electron, Scanning
/
Cell Survival
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Stomatology
Year:
2003
Type:
Article
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