The role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cells apoptosis / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cell apoptosis.</p><p><b>METHODS</b>Western blot analysis was used to investigate the expression of the mitogen-activated protein kinase.</p><p><b>RESULTS</b>When treated with PYM in cultured KB cells, the extracellular signal-regulated kinase (ERKl/2) showed a dose-and time-dependent decreasing in phosphorylation status of these proteins through a western blot analysis, whereas protein levels of p38 MAPK remained unchanged.</p><p><b>CONCLUSIONS</b>The mitogen-activated protein kinase (MAPK) pathway may play an important ro1e in PYM-induced apoptosis of KB cells.</p>