Relation between the expression of P-gp and GST-pi in oral and maxillofacial squamous carcinoma and chemoresistance / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 90-93, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-347361
ABSTRACT
<p><b>OBJECTIVE</b>To investigating the relation between the expression of P-glycoprotein and Glutathione transferase-pi and the chemoresistance.</p><p><b>METHODS</b>The expressions of these two proteins in patients with oral and maxillofacial squamous carcinoma and normal oral tissues were detected by immunohistochemistry.</p><p><b>RESULTS</b>The positive expression rate of P-gp and GST-pi in oral and maxillofacial malignant tumor was 57.1% and 53.6% respectively, and no expression in normal oral tissues; the expression of GST-pi was relevant to the resistance to cisplatin, while the expression of P-gp was relevant to the resistance to chemotherapeutic drug in general.</p><p><b>CONCLUSIONS</b>The method of immunohistochemistry combining MTT assay in vitro may become an efficient way to predict the sensitivity to chemotherapeutic drug.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tetrazolium Salts
/
Facial Neoplasms
/
Mouth Neoplasms
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Maxillary Neoplasms
/
Chemistry
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
Drug Resistance, Neoplasm
/
Drug Therapy
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Stomatology
Year:
2002
Type:
Article
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