Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1beta production from human phagocytes
Experimental & Molecular Medicine
;
: 584-591, 2009.
Article
in English
| WPRIM
| ID: wpr-34741
ABSTRACT
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Phagocytes
/
Serum Amyloid A Protein
/
Lysophospholipids
/
Monocytes
/
Chemotaxis, Leukocyte
/
Receptors, Lipoxin
/
Receptors, Formyl Peptide
/
Interleukin-1beta
/
Neutrophils
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2009
Type:
Article
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