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Expression of EP-CAM, beta-catenin in the carcinogenesis of squamous cell carcinoma of uterine cervix / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 372-375, 2003.
Article in Chinese | WPRIM | ID: wpr-347421
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of EP-CAM, beta-catenin in the carcinogenesis of squamous cell carcinoma of uterine cervix.</p><p><b>METHODS</b>The expressions of EP-CAM and beta-catenin were detected with immunohistochemical stain in 14 cases of normal cervical squamous epithelium, 32 cases of cervical intraepithelial neoplasia (CIN) and 38 cases of cervical invasive squamous cell carcinoma.</p><p><b>RESULTS</b>The over-expression rates of EP-CAM were 0, 7.1%, 20.0%, 62.5% and 55.3% for normal cervical epithelium, CINI, CINII, CINIII and carcinoma groups. The EP-CAM over-expression rates in CINIII and cervical carcinoma groups were significantly higher than those in normal epithelium and CINI groups (P < 0.001). No aberrant expression of beta-catenin was shown in normal cervical epithelium, while the aberrant expression rates of beta-catenin in CINI, CINII, CINIII and cervical carcinoma group were 28.6%, 40.0%, 62.5% and 84.2%. The aberrant expression rate of beta-catenin increased with the increase in degree of CIN and development of cervical carcinoma. The over-expression rate of EP-CAM was reversely related to the differentiation of cervical squamous cell carcinoma (P < 0.001).</p><p><b>CONCLUSION</b>EP-CAM and beta-catenin may be involved in the carcinogenesis of squamous cell carcinoma of uterine cervix. The over-expression of EP-CAM and aberrant expression of beta-catenin may serve as markers of squamous carcinogenesis of uterine cervix.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Carcinoma, Squamous Cell / Biomarkers, Tumor / Cadherins / Cell Adhesion Molecules / Trans-Activators / Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Cervix Uteri / Disease Progression / Cell Biology Limits: Female / Humans Language: Chinese Journal: Chinese Journal of Oncology Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Carcinoma, Squamous Cell / Biomarkers, Tumor / Cadherins / Cell Adhesion Molecules / Trans-Activators / Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Cervix Uteri / Disease Progression / Cell Biology Limits: Female / Humans Language: Chinese Journal: Chinese Journal of Oncology Year: 2003 Type: Article