Expression of heparanase mRNA and its clinical significance in primary hepatocellular carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 359-361, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-347425
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of heparanase mRNA and its relation with the clinicopathological features and angiogenesis in primary hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>Expression of heparanase mRNA was detected by RT-PCR in 51 HCC lesions, and microvessel density (MVD) was detected by immunohistochemical stain with a factor VIII-related monoclonal antibody.</p><p><b>RESULTS</b>Expression of heparanase mRNA was shown in 49.0% (25/51) HCC lesions. The positive rate of heparanase expression in tumors larger than 3 cm (63.6%, 21/33) was significantly higher than those in smaller tumors (22.2%, 4/18; P < 0.01). Heparanase expression was more frequent in highly invasive tumors (70.0%, 14/20) compared with moderately invasive tumors (46.7%, 7/15) and low invasive ones (25.0%, 4/16; P < 0.05). Moreover, heparanase expression in tumors with high MVD (62.5%, 20/32) was significantly higher than those in tumors with low MVD (26.3%, 5/19; P < 0.05).</p><p><b>CONCLUSION</b>Heparanase mRNA expression may be important for the growth, invasion and angiogenesis of hepatocellular carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Carcinoma, Hepatocellular
/
Tumor Burden
/
Genetics
/
Glucuronidase
/
Liver
/
Liver Neoplasms
/
Microcirculation
/
Neoplasm Invasiveness
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2003
Type:
Article
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