Post-mastectomy radiotherapy with different fractionated dose schemes in early breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 285-288, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-347440
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of post-mastectomy radiotherapy with different fractionated dose schemes for early breast cancer.</p><p><b>METHODS</b>From January 1987 to January 1993, 367 patients with early breast cancer were given post-mastectomy radiotherapy with three different fractionated dose schemes. 149 patients received conventional radiotherapy with 50 Gy/25 fractions/5 weeks (Group A). 177 patients received 45 Gy/15 fractions/5 weeks (Group B). Forty-one patients were treated with 23 Gy/4 fractions/17 days (Group C). 257 patients received systemic therapy (chemotherapy and/or endocrine therapy).</p><p><b>RESULTS</b>The overall 5-year survival and 5-year disease-free survival rates were 87.4% and 89.6%. The 5-year disease-free survival rate were 90.8%, 86.5% and 84.6% for A, B and C groups (P = 0.16). The corresponding loco-regional failure rates were 2.7%, 2.8% and 2.4%, respectively. There was no statistically significant difference in the local control and efficacy of the three groups.</p><p><b>CONCLUSION</b>With similar 5-year tumor-free survival rates by the conventional fractionation and hypofractionation, the scheme with 45 Gy/15 fractions/5 weeks has the advantage of giving less factions, which is suitable for a unit with limited radiation resources. The course of hypofractionation with 23 Gy/4 fractions/17 days is much shorter than conventional radiotherapy, which may benefit patients with higher risk of metastasis who need to undergo chemotherapy earlier. This study warrants further investigations.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiotherapy
/
General Surgery
/
Breast Neoplasms
/
Survival Rate
/
Mortality
/
Combined Modality Therapy
/
Dose Fractionation, Radiation
/
Mastectomy
/
Neoplasm Recurrence, Local
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS