Recombinant human interleukin-11 in the prevention of chemotherapy-induced thrombocytopenia / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 272-274, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-347444
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of domestic recombinant human interleukin-11 (rhIL-11) in the prevention of chemotherapy-induced thrombocytopenia.</p><p><b>METHODS</b>A randomized, self-crossover and placebo-controlled trial was conducted, with rhIL-11 and placebo classified randomly as drug A and drug B. Patients were randomly assigned to group AB or group BA. 25 microg/kg body weight of drug A or drug B was administered subcutaneously once daily starting 24 hours after chemotherapy and continued for 7 to 14 days or until the platelet count reached > or = 300 x 10(9)/L.</p><p><b>RESULTS</b>118 patients were evaluable in the efficacy study. When compared with the placebo treated cycle, the results showed that rhIL-11 was able to significantly increase the platelet count at the nadir and d21 after chemotherapy, with a increase of 60.7% and 86.1% (both P < 0.001). The mean duration of thrombocytopenia (< 100 x 10(9)/L) in rhIL-11 treated cycle was 1.0 +/- 2.0 days as compared to 6.9 +/- 5.3 days in placebo treated cycle. The side effects were ache (24.6%), swelling (16.1%) and knurl (11.9%) at the injection site, hyperaemia of conjunctiva (16.1%), edema (8.5%), palpitation (6.8%) and fatigue (5.1%).</p><p><b>CONCLUSION</b>rhIL-11, possessing significant thrompoietic activity, significantly increases the likelihood of avoiding chemotherapy-induced thrombocytopenia and shorten the duration of thrombocytopenia. Its side effects are mild and manageable.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thrombocytopenia
/
Blood
/
Recombinant Proteins
/
Double-Blind Method
/
Interleukin-11
/
Cross-Over Studies
/
Therapeutic Uses
/
Drug Therapy
/
Neoplasms
/
Antineoplastic Agents
Type of study:
Controlled clinical trial
Limits:
Adolescent
/
Adult
/
Aged
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2003
Type:
Article
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