Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappa B pathway in human dermal fibroblasts
Experimental & Molecular Medicine
;
: 548-554, 2009.
Article
in English
| WPRIM
| ID: wpr-34745
ABSTRACT
Cordycepin (3'-deoxyadenosine) has been shown to exhibit many pharmacological activities, including anti-cancer, anti-inflammatory, and anti-infection activities. However, the anti-skin photoaging effects of cordycepin have not yet been reported. In the present study, we investigated the inhibitory effects of cordycepin on matrix metalloproteinase-1 (MMP-1) and -3 expressions of the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed cordycepin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB strongly activated NF-kappa B activity, which was determined by I kappa B alpha degradation, nuclear localization of p50 and p65 subunit, and NF-kappa B binding activity. However, UVB-induced NF-kappa B activation and MMP expression were completely blocked by cordycepin pretreatment. These findings suggest that cordycepin could prevent UVB-induced MMPs expressions through inhibition of NF-kappa B activation. In conclusion, cordycepin might be used as a potential agent for the prevention and treatment of skin photoaging.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Ultraviolet Rays
/
Aging
/
Gene Expression Regulation, Enzymologic
/
Cells, Cultured
/
Enzyme Induction
/
Deoxyadenosines
/
NF-kappa B
/
Matrix Metalloproteinase 3
/
Dermis
Limits:
Humans
/
Male
/
Infant, Newborn
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2009
Type:
Article
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