A serial study of in cytogenetic change and morphology on the tetra-arsenic tetra-sulfide treatment in untreated or recurrent acute promyelocytic leukemia / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 163-167, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-347469
ABSTRACT
<p><b>OBJECTIVE</b>To study the morphologic and cytogenetic change in acute promyelocytic leukemia (APL) patients during the tetra-arsenic tetra-sulfide (TATS) treatment and the mechanism of TATS.</p><p><b>METHODS</b>The bone marrow cells of 13 newly diagnosed and 7 recurrent APL patients were studied through FISH and morphology during the TATS treatment by special and repeated marrow culture.</p><p><b>RESULTS</b>Cytomorphological study of 8 cases (6 untreated and 2 recurrent) showed that TATS could differentiate APL cells forward to mature granulocytes. There was obvious correlation between the reduced t (15; 17) positive cells and the reduced APL cells (r range 0.7298 - 0.9989). Except one patient with t (11; 17), 19 (13 untreated and 7 recurrent) with translocation t (15; 17) achieved clinical CR including 16 who achieved cytogenetic CR.</p><p><b>CONCLUSION</b>TATS has a differentiation-inducing effect on untreated and recurrent APL, with haematological CR and cytogenetic CR achieved. Measurement of t (15; 17) positive cells by FISH technique can reflect the change of APL cells objectively.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Arsenicals
/
Recurrence
/
Sulfides
/
Translocation, Genetic
/
Bone Marrow
/
Chromosomes, Human, Pair 15
/
Chromosomes, Human, Pair 17
/
Leukemia, Promyelocytic, Acute
/
In Situ Hybridization, Fluorescence
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2003
Type:
Article
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