Expression of different RASSF1 transcripts and its clinical significance in lung carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 149-152, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-347473
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the expression of three different RASSF1 transcripts and its clinical significance in lung carcinomas.</p><p><b>METHODS</b>The mRNA expression of RASSF1A, RASSF1B and RASSF1C was detected by RT-PCR in 51 human lung cancer tissues and 51 matched normal tissues.</p><p><b>RESULTS</b>1. The mRNA expression of three RASSF1 transcripts was detectable in all non-cancer tissues. However, high rate of expression loss of RASSF1A and RASSF1B existed in lung cancer tissues, which was 53.2% (2851) and 37.3% (19/51), respectively. RASSF1C was expressed in all of the tumor tissues. 2. Loss or abnormal down-regulation of RASSF1A was positively related with lymph node metastasis and TNM stage (P < 0.05) and 3. RASSF1B and RASSF1C mRNA expression was not correlated with TNM stage, histological type, differentiation grade or smoking index.</p><p><b>CONCLUSION</b>There is a significant expression difference among the three RASSF1 transcripts in lung carcinoma. RASSF1A, closely associated with lymph metastasis and TNM stage of lung carcinoma, should be a new tumor suppressor gene.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Chromosomes, Human, Pair 3
/
RNA, Messenger
/
Genes, Tumor Suppressor
/
Chromosome Deletion
/
Tumor Suppressor Proteins
/
Genetics
/
Lung Neoplasms
/
Lymphatic Metastasis
/
Neoplasm Staging
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2003
Type:
Article
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