Multi-variate regression analysis of clinicopathological characteristics and prognosis of colorectal cancer / 中华肿瘤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the relationship between clinicopathologic features and prognosis of colorectal cancer after surgical treatment.</p><p><b>METHODS</b>The clinical characteristics, pathologic features and survival rate of 761 patients with colorectal cancer after surgical treatment were univariately and multivariately analyzed.</p><p><b>RESULTS</b>The overall 3- and 5-year survival rates of patients with colorectal cancer after surgical treatment were 62.9% and 60.7% with a median survival of 1,825 days. The factors of gross findings, degree of differentiation, infiltration, nodal and distant metastasis and neoplastic intestinal obstruction influenced the survival rate by univariate analysis. The factors of Dukes stage, gross tumor configuration, intramural spread and differentiation degree were available independent prognostic factors through multivariate analysis.</p><p><b>CONCLUSION</b>Dukes stage, as the most important available independent prognostic factor (P < 0.0005), is able to assess the postoperative survival.</p>