Expression of myeloid cell triggering receptor-1 in monocytes at early post-burn stage / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 276-279, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-347688
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of triggering receptor expressed on myeloid cells (TREM-1) in monocytes of burn patients at early post-burn stage, and its significance.</p><p><b>METHODS</b>The monocytes of 8 healthy volunteers (A group), 29 patients with mild and moderate burn (B group), and 9 patients with severe and very serious burns (C group) were isolated from the blood, and the THEM-1 mRNA and protein expression were determined by semi-quantitative RT-PCR and flow cytometry, respectively. The plasma levels of TNF-alpha, IL-1beta were determined by ELISA method.</p><p><b>RESULTS</b>The value of TREM-1 mRNA expression in A, B and C groups were 0.74 +/- 0.13, 1.24 +/- 0.09, and 1.46 +/-0.07, respectively, and the expression rates on cell surface in the 3 groups were (9 +/- 4)%, (51 +/- 6)%, and (71 +/- 7)%, respectively, and there were significant differences among the three groups (P = 0.000). the plasma levels of TNF-alpha and IL-1beta in B and C groups were obviously higher than that in A group (P = 0.000), and they were positively correlated to TREM-1 expression (rs = 0.68, 0.72, P = 0.000).</p><p><b>CONCLUSION</b>Increased expression of TREM-1 in monocytes of burn patients at early post-burn stage is correlated with the release of inflammatory factors, indicating that TREM-1 might contribute to the onset and development of acute inflammatory response after burns.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Burns
/
RNA, Messenger
/
Membrane Glycoproteins
/
Monocytes
/
Receptors, Immunologic
/
Interleukin-1
/
Tumor Necrosis Factor-alpha
/
Myeloid Cells
/
Triggering Receptor Expressed on Myeloid Cells-1
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Burns
Year:
2007
Type:
Article
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