The influence of early enteral immunonutrition on immunological function of body and intestine in severely scalded rats / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 257-260, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-347693
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of early enteral immunonutrition on immunological function of body and intestine in severely scalded rats.</p><p><b>METHODS</b>Sixty-four healthy adult SD rats were subjected to 30% TBSA full-thickness scald and randomly divided into enteral nutrition group (EN, n = 32) and enteral immunonutrition group (EIN, n = 32). Another 8 healthy rats were enrolled as normal controls. The changes in CD3+, CD4+, CD8+ T lymphocyte subsets, the PCNA expression in intestinal mucosa,the amount of plasmocytes in lamina propria of small intestine and the content of s-IgA in small intestine were determined on 1, 4, 7 and 10 post-burn days (PBD).</p><p><b>RESULTS</b>(1) CD3+, CD4+ and the ratio of CD4+/CD8+ were remarkably declined, while CD8+ was obviously raised after scald in EN group, and there were statistically significant differences at most of time-points when compared with those in control group (P < 0.05 or P < 0.01). CD3+, CD4+ and the ratio of CD4+/CD8+ on 7 and 10 PBD in EIN group were obviously higher (increased from 4 PBD on, and it was 1.86 +/- 0.25 on 10 PBD) than those in EN group (CD4+/CD8+ was 1.26 +/- 0.10 on 10 PBD), while CD8+ in EIN group was evidently lower than that in EN group (P < 0.01). (2) The level of PCNA expression in intestinal mucosa, the amount of plasmocytes in lamina propria of small intestine and the content of s-IgA in small intestine in EIN group were increased significantly compared with EN group on 4, 7, 10 PBD (P < 0.05 or P < 0.01).</p><p><b>CONCLUSION</b>Early enteral immunonutrition can improve immunological function of body and intestine after severe scald, with better results than enteral nutrition.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arginine
/
Therapeutics
/
Burns
/
Immunoglobulin A, Secretory
/
Random Allocation
/
CD4-CD8 Ratio
/
Enteral Nutrition
/
Rats, Sprague-Dawley
/
Proliferating Cell Nuclear Antigen
/
Allergy and Immunology
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Burns
Year:
2007
Type:
Article
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