Application and evaluation of biologic potential grading criteria for localized gastrointestinal stromal tumors / 中华病理学杂志
Chinese Journal of Pathology
; (12): 649-653, 2007.
Article
in Zh
| WPRIM
| ID: wpr-347705
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the implication of Fletcher and Miettinen biologic potential grading criteria in native localized gastrointestinal stromal tumors (GISTs).</p><p><b>METHODS</b>Two hundred and twenty localized GISTs with complete clinicopathologic and follow-up data were evaluated for their biologic potential by Fletcher and Miettinen grading criteria. The implication of the two grading criteria were compared by survival analysis.</p><p><b>RESULTS</b>Evaluated by Fletcher grading criteria, the overall and disease-free survival rate of high risk GISTs was lower than that of very-low, low and intermediate GISTs; while the overall and disease-free survival rate of very-low, low and intermediate risk GISTs had no statistical diffence. In the high risk GISTs, the overall and disease-free survival rate of small intestinal and rectal GISTs was lower than that of gastric GISTs; while in the intermediate risk GISTs, the disease-free survival rate of small intestinal GISTs was lower than that of gastric GISTs. Evaluated by Miettinen grading criteria, the overall and disease-free survival rate of high risk GISTs was lower than that of very-low, low and intermediate GISTs; while the overall and disease-free survival rate of very-low, low and intermediate risk GISTs had no statistical difference. In the risk subgroup of GISTs, the overall and disease-free survival rate of gastric, small intestinal and rectal GISTs had no statistical difference.</p><p><b>CONCLUSIONS</b>Fletcher grading criteria is simple and easy to use; while Miettinen grading criteria for evaluating biological potential by anatomic site is more critical and has important reference implication for the selection of high risk patients for targeted adjuvant treatment.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Rectal Neoplasms
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Reference Standards
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Stomach Neoplasms
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Survival Rate
/
Follow-Up Studies
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Risk Assessment
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Disease-Free Survival
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Disease Progression
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Gastrointestinal Stromal Tumors
Type of study:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Pathology
Year:
2007
Type:
Article