Expression of neutral endopeptidase and motility-related protein-1 in cutaneous malignant melanoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 466-469, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-347757
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of neutral endopeptidase (CD10) and motility-related protein-1 (CD9) in malignant melanoma and their clinical significance.</p><p><b>METHODS</b>Immunohistochemical study for CD10 and CD9 using Streptavidin-biotin complex technique was carried out in 48 cases of primary cutaneous malignant melanoma (CMM), 23 cases of metastatic melanoma and 23 cases of benign nevus.</p><p><b>RESULTS</b>The positivity rate of CD10 was highest in metastatic melanoma and lowest in benign nevus (P < 0.01). In contrast, the positivity rate of CD9 in metastatic melanoma was lower than that in CMM (P < 0.05). The expression of CD9 was inversely correlated with that of CD10 in malignant melanoma (CMM r = -0.40, P = 0.005; metastatic MM r = -0.44, P = 0.034). The expression of CD10 and CD9 in CMM also correlated with tumor histology, Clark's level of invasion and presence of nodal metastasis. A similar relationship was also observed for CD10 and CD9 expression in stromal fibroblasts of CMM (r = -0.43, P = 0.007).</p><p><b>CONCLUSIONS</b>CD10 and CD9 expression correlates with the invasiveness and metastatic potential of malignant melanoma; both factors may demonstrate a counteracting effect. These two markers have potential implications in prognostic assessment of CMM. Stromal fibroblasts may also play an important role in the progression of CMM.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Skin Neoplasms
/
Membrane Glycoproteins
/
Neprilysin
/
Antigens, CD
/
Gene Expression Regulation, Neoplastic
/
Tetraspanin 29
/
Lymphatic Metastasis
/
Melanoma
/
Metabolism
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2007
Type:
Article
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