Progress of studies on VEC apoptosis-inducing proteins in snake venom and its mechanism--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 708-712, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-347879
ABSTRACT
Hemorrhagic snake venom specially induces apoptosis of VEC (vascular endothelial cells). Five apoptosis-inducing proteins had been purified and characterized from crude snake venom. Two of these are L-amino acid oxidase (LAO), the others belong to metalloprotease/disintegrin family. LAO catalyzes H2O2 production by oxidizing some plasma membrane proteins of VEC, disintegrins interfere with binding of integrins with their ligands. The expression of p53 and bcl-2 increases during VEC apoptosis induced by snake venom, moreover, the mRNA of bcl-2 is spliced into two fragments. It has been proved that one of adhesion-dependent signal molecules, alphavbeta3, and one of phospholipid signal molecules, PC-PLC (phosphatidylcholine-specific phospholipase C), are involved in above apoptosis-inducing signal transudation pathway. These results throw light on finding out specific component from protein is snake venom. This component is able to induce tumor vascular endothelial cells apoptosis. This review summarized progress of research on hemorrhagic snake venoms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Snake Venoms
/
Signal Transduction
/
Chemistry
/
Gene Expression Regulation
/
Reactive Oxygen Species
/
Apoptosis
/
Cell Biology
/
Endothelial Cells
/
L-Amino Acid Oxidase
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2004
Type:
Article
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