Correlation between ABO blood type gene and attention-deficit hyperactivity disorder in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 371-373, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-347912
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between ABO blood type gene and attention-deficit hyperactivity disorder (ADHD) in children.</p><p><b>METHODS</b>ABO blood types were determined using glass sheet method in 96 children with ADHD and their parents. O gene was identified using polymerase chain reaction and restriction fragment length polymorphism in patients with A or B blood type. Haplotype-based haplotype relative risk (HHRR), transmission-disequilibrium test (TDT) and Chi-square test were used to examine the association between ABO gene and ADHD.</p><p><b>RESULTS</b>TDT results showed significant differences in the allele of ABO between the 96 children with ADHD and within-family controls (chi2=6.017, df=2, P< 0.05). Chi-square test results showed differences in the allele of A and B (chi2=3.289, df=1, P=0.07) as well as O and B (chi2=3.629, df=1, P=0.057 ) between ADHD children and within-family controls. The frequencies of O and A genes were higher than that of B gene in ADHD children.</p><p><b>CONCLUSIONS</b>There was correlation between ABO blood type gene and ADHD in children. The risk of ADHD is increased in the presence of alleles O and A, but the risk is reduced in the presence of allele B.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Attention Deficit Disorder with Hyperactivity
/
Blood
/
ABO Blood-Group System
/
Haplotypes
/
Alleles
/
Genetics
Type of study:
Etiology study
/
Prognostic study
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2009
Type:
Article
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