Neurobehavioral function of neonatal mice following excitotoxic brain damage / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 191-193, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-347966
ABSTRACT
<p><b>OBJECTIVE</b>To assess the changes of neurobehavioral function in a neonatal mouse model of excitotoxic brain damage.</p><p><b>METHODS</b>Fifty-five 5-day-old ICR neonatal mice were randomly assigned to three groups blank (no intravenous) control (n=20), saline control (n=20) and excitotoxic brain damage model (ibotenic acid treatment, n=15). Behavioral function was evaluated by the surface righting reflex test (postnatal days 6-10), the swimming test (postnatal days 8-12) and the Y-maze discrimination learning test (postnatal days 33-34).</p><p><b>RESULTS</b>Righting time in the surface righting reflex test in the ibotenic acid treatment group on postnatal days 6-10 was more prolonged than that in the two control groups (p<0.05). Swimming test scores in the ibotenic acid treatment group were significantly lower than those in the two control groups (p<0.05). In the Y-maze discrimination learning test, the mice from the ibotenic acid treatment group performed significantly worse than two control groups, presenting with increased learning times (19.79+/-2.42 vs 16.29+/-2.48 or 16.30+/-2.37; p<0.05) and achieving a lower correct percentage (86.7% vs 96.5% or 95.0%) (p<0.05).</p><p><b>CONCLUSIONS</b>The developmental reflexes and learning and memory functions were impaired in neonatal mice following excitotoxic brain damage. Behavioral testing is useful in the evaluation of early developmental reflexes and long-term neurobehavioral outcome in neonatal mice with excitotoxic brain damage.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Swimming
/
Behavior, Animal
/
Brain
/
Maze Learning
/
Excitatory Amino Acid Agonists
/
Toxicity
/
Ibotenic Acid
/
Animals, Newborn
/
Mice, Inbred ICR
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2009
Type:
Article
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