Clinical significance of anti-D IgG screening and titer detection in 286 RhD negative pregnant women / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 185-187, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-347968
ABSTRACT
<p><b>OBJECTIVE</b>Anti-D IgG in RhD negative pregnant women is the main antibody of Rh-induced hemolytic disease of newborn (HDN). The study aimed to investigate the clinical significance of anti-D IgG screening and titer detection in RhD negative pregnant women.</p><p><b>METHODS</b>Sera of 286 RhD negative pregnant women were collected. Microtube column indirect antiglobulin test was used to screen and identify anti-D IgG. The indirect antiglobulin test was used to test the titer of anti-D IgG.</p><p><b>RESULTS</b>Anti-D IgG was identified in 21 cases (7.3%). The titer of anti-D showed an increasing trend with pregnancy progresses. The clinical outcomes of 12 fetuses (newborns) from positive anti-D pregnant women were observed. Two cases died in utero, 2 cases did not show abnormality and 8 cases had hemolysis. The 8 cases with hemolysis were treated with exchange transfusion or blood transfusion, and they had a good prognosis.</p><p><b>CONCLUSIONS</b>The screening and titer detection of anti-D IgG in RhD negative pregnant women are valuable in the prediction and treatment of HDN.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rh-Hr Blood-Group System
/
Blood
/
Blood Group Incompatibility
/
ABO Blood-Group System
/
Immunoglobulin G
/
Rho(D) Immune Globulin
/
Diagnosis
/
Allergy and Immunology
/
Erythroblastosis, Fetal
/
Isoantibodies
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2009
Type:
Article
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