Analyses of differential expression of Homeobox genes between lingual squamaous cell carcinoma and normal mucosa / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 500-503, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-348008
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the differently expressed Homeobox genes between lingual squmaous cell carcinoma and normal mucosa.</p><p><b>METHODS</b>Seven paired specimens including lingual squmaous cell carcinoma and its surrounding normal tissue were obtained from 7 patients. Customized Oligo microarray which contains numerous probes of 232 human Homeobox genes was used to analyse the results. All datas were scanned by Agilent scanner and differentiately expressed genes were sorted out.</p><p><b>RESULTS</b>Homeobox gene NANOG was found up-regulated in 5 samples. PHTF2 was found down-regulated in 7 samples, and CRX, PITX1, OTEX was found down-regulated in 5 samples.</p><p><b>CONCLUSION</b>As the key gene to cellular proliferation and differentiation, Homeobox genes is closely releverant to the oncogenesis of lingual squmaous cell carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gene Expression Regulation, Neoplastic
/
Cell Differentiation
/
Genes, Homeobox
/
Mucous Membrane
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2007
Type:
Article
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