Changes in expression of gelatinase in young rat condylar cartilage during functional mandibular advancement / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 299-305, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-348097
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes in expression of gelatinase (MMP-2, MMP-9) in young rat condylar cartilage during functional mandibular advancement.</p><p><b>METHODS</b>Sixty male 5-week old SD rats were divided into experimental and control groups. The mimic functional appliances were used in experimental group rats. The animals were sacrificed after 1, 2, 4 weeks. The immunoreactivity of gelatinase was detected by immunohistochemistry.</p><p><b>RESULTS</b>In normal mandibular condylar cartilage, the immunoreactivity of MMP-2 was rather strong, the immunoreactivity of MMP-9 was very weak. Following functional mandibular advancement, the expression of MMP-9 was significantly increased (P < 0.01), but immunoreactivity of MMP-2 had no significant changes.</p><p><b>CONCLUSION</b>Gelatinase plays an important role in the adaptive remondling of young rat condylar cartilage during functional mandibular advancement.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cartilage
/
Rats, Sprague-Dawley
/
Gelatinases
/
Mandibular Advancement
/
Matrix Metalloproteinase 2
/
Mandibular Condyle
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2007
Type:
Article
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