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Low dose-intensity docetaxel monotherapy for patients with anthracycline-resistant metastatic breast cancer in poor physical status / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 317-319, 2008.
Article in Chinese | WPRIM | ID: wpr-348103
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of a weekly schedule of low dose-intensity docetaxel monochemotherapy for patients with anthracycline-resistant metastatic breast cancer (MBC) in poor physical status.</p><p><b>METHODS</b>Thirty MBC patients who were previously exposed to anthracycline treatment received docetaxel alone at a dose of 30 mg/m2 on D1, D8 and D15, repeated every 4 weeks for a maximum of 6 cycles.</p><p><b>RESULTS</b>Of the 30 evaluable patients, 2 (6.7%) achieved a complete response, and 9 (30.0%) a partial response, with an overall objective response rate of 36.7% (95% CI 20.5%-53.9%). The most common adverse event was hematologic toxicity. After an average follow-up of 15.0 months, the median time to progression (TTP) was 8. 5 months and the median overall survival (OS) had not reached yet at the end of follow-up.</p><p><b>CONCLUSION</b>The weekly low dose-intensity docetaxel monochemotherapy is effective and well-tolerated in patients with anthracycline-resistant metastatic breast cancer in poor physical status.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Remission Induction / Breast Neoplasms / Survival Rate / Follow-Up Studies / Carcinoma, Lobular / Carcinoma, Ductal, Breast / Drug Resistance, Neoplasm / Anthracyclines / Taxoids Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans Language: Chinese Journal: Chinese Journal of Oncology Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Remission Induction / Breast Neoplasms / Survival Rate / Follow-Up Studies / Carcinoma, Lobular / Carcinoma, Ductal, Breast / Drug Resistance, Neoplasm / Anthracyclines / Taxoids Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans Language: Chinese Journal: Chinese Journal of Oncology Year: 2008 Type: Article