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The levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children
Clinical and Molecular Hepatology ; : 382-388, 2013.
Article in English | WPRIM | ID: wpr-34827
ABSTRACT
BACKGROUND/

AIMS:

Infectious mononucleosis (IM) is the clinical presentation of primary infection with Epstein-Barr virus. Although the literature contains a massive amount of information on IM, most of this is related specifically to only children or adults separately. In order to distinguish any differences between preschool children and youth patients, we retrospectively analyzed their demographic and clinical features.

METHODS:

Records of patients hospitalized from December 2001 to September 2011 with a diagnosis of IM were retrieved from Peking University First Hospital, which is a tertiary teaching hospital in Beijing. The demographic data and clinical characteristics were collected.

RESULTS:

IM was diagnosed in 287 patients during this 10-year period, with incidence peaks among preschool children (15 and <24 years old, 101/287, 35.2%). Although the complaints at admission did not differ between these two patient groups, the incidence of clinical signs (tonsillopharyngitis, lymphadenopathy, hepatomegaly, and edema of the eyelids) was much higher in preschool children. The incidence of liver lesion and percentage of atypical lymphocytes were significantly higher in the youth group (P<0.001), and the average hospital stay was longer in this group. Pneumonia was the most common complication, and there was no case of mortality.

CONCLUSIONS:

The incidence of IM peaks among preschool children and youth patients in Beijing, China. The levels of liver enzymes and atypical lymphocytes increase with age.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Aspartate Aminotransferases / Lymphocytes / Pharyngitis / Demography / Incidence / Retrospective Studies / Alanine Transaminase / Fever / Gamma-Glutamyltransferase / Infectious Mononucleosis Type of study: Incidence study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Humans / Infant Language: English Journal: Clinical and Molecular Hepatology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Aspartate Aminotransferases / Lymphocytes / Pharyngitis / Demography / Incidence / Retrospective Studies / Alanine Transaminase / Fever / Gamma-Glutamyltransferase / Infectious Mononucleosis Type of study: Incidence study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Humans / Infant Language: English Journal: Clinical and Molecular Hepatology Year: 2013 Type: Article