Effects of growth differentiation factor-15 (GDF-15) on neurological systems, cardiovascular diseases, and cancer progression / 生理学报
Acta Physiologica Sinica
;
(6): 109-121, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-348293
ABSTRACT
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor beta superfamily. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. It has been suggested that GDF-15 has neurotropic effects in the nervous system. Our studies showed that GDF-15 modulated the expression of neuronal Kand Caion channels and increased the release of excitatory transmitter in the medial prefrontal cortex of mice. GDF-15 is also involved in the complex modulation of cancer and cardiovascular disease. Here, we reviewed studies involving the modulation of GDF-15 expression and its mechanisms, the primary pathological and physiological functions of GDF-15 in neurological and cardiovascular systems, and its role in cancer progression. The biological effects and the values of GDF-15 in basic research and clinical applications were also addressed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain Injuries
/
Calcium Channels
/
Cardiovascular Diseases
/
Potassium Channels
/
Up-Regulation
/
Transforming Growth Factor beta
/
Prefrontal Cortex
/
Disease Progression
/
Growth Differentiation Factor 15
/
Inflammation
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2017
Type:
Article
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