Effect of central obesity on the events of new-onset cerebral infarction among type 2 diabetes mellitus patients / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the effect of central obesity on new-onset cerebral infarction events among type 2 diabetes mellitus patients in the Kailuan Group.</p><p><b>METHODS</b>This was a prospective cohort study. In a total of 101 510 employees who had been carried out a healthy examination in Kailuan Group from Jul. 2006 to Oct. 2007. 8 306 type 2 diabetes mellitus patients were selected. According to the baseline waist measurement, the observed population was divided into two groups-with central obesity or without. The total period of follow-up was 38-53 (48.05 ± 3.09) months.</p><p><b>RESULTS</b>1) Mean age, BMI, the levels of SBP, DBP, pulse pressure, FPG, TC, LDL-C, uric acid significant increased in the central obesity group were higher than in the non-obese group (P < 0.01). 2) The incidence of new onset cerebral infarction in obese group was higher than that in the non-obese group (3.1% vs. 1.6%, 6.8%, P < 0.01; 3.3% vs. 1.7%, P < 0.01 in male respectively. 3) Results from the multiple logistic regression analysis showed that, compared with the non-obese group, the obese group had an increase of relative risk (RR) on new onset cerebral infarction events after adjustment on age, gender and other risk factors, with RR value as 2.07 (95%CI1.39-3.09, P < 0.01).</p><p><b>CONCLUSION</b>Type 2 diabetes mellitus patients with central obesity seemed to have increased the risk of new-onset cerebral infarction events.</p>