Advances in parallel artificial membrane permeability assay and its applications / 药学学报
Acta Pharmaceutica Sinica
;
(12): 890-895, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-348887
ABSTRACT
With the development of drug discovery, more and more candidate compounds need to be studied. Methods that can screen compound rapidly received significant attention. Parallel artificial membrane permeability assay (PAMPA) as a powerful tool has been applied to drug studies. It uses an artificial lipid membrane to mimic the barrier for drug permeability studies. This article introduces the establishment and characteristics of PAMPA, as well as its applications in screening compounds. It can be used as models (e.g. predicting the ability of compound in gastro-intestinal absorption, blood-brain barrier transportation and skin penetration) by changing the component of artificial lipid membrane. PAMPA has advantages in high throughput selection of valuable compound with low cost, versatile, low dose, and good reproducibility.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Skin Absorption
/
Stomach
/
Pharmaceutical Preparations
/
Blood-Brain Barrier
/
Cell Membrane Permeability
/
Absorption
/
Intestinal Absorption
/
Membranes, Artificial
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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