Thermosensitive in situ gel of boanmycin hydrochloride for injection / 药学学报
Acta Pharmaceutica Sinica
;
(12): 727-732, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-348893
ABSTRACT
Poloxamer F127, poloxamer F68 and hydroxypropyl methylcellulose K4M were used to prepare the thermosensitive in situ gel of boanmycin hydrochloride for injection. Its gelation temperature, rheological behavior, texture characteristics, scanning electron microscopy, in vitro and in vivo drug release were evaluated. These results showed that the formulation was a fluid solution at room temperature, which could become semisolid at the temperature of 37 degrees C, and the thermally induced sol-gel transition allowed to be injectable and in situ setting. The formulation was constructed into a tridimensional network at gelation temperature. The drug release was controlled by the diffusion of the drug and the erosion of the gelmatrix. The pharmacokinetics indicated that the drug could be released slowly for up to 48 hours after subcutaneous administration in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rheology
/
Temperature
/
Viscosity
/
Bleomycin
/
Pharmacokinetics
/
Microscopy, Electron, Scanning
/
Chemistry
/
Drug Delivery Systems
/
Rats, Sprague-Dawley
/
Poloxamer
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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