Advances in the structure-activity relationship study of natural flavonoids and its derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 622-630, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-348909
ABSTRACT
Flavonoids are a large class of compounds widely distributed in nature. Many pharmacological activities of flavonoids have been reported such as anti-cancer, antioxidant, anti-inflammatory, hepatoprotective, antithrombotic, vasodilator, antiviral, antibacterial, antiallergic, and so on. In recent years, domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities. As part of the mechanisms are not clear, we need to strengthen in-depth research in the SAR (structure-activity relationship) study for targeted and efficient structure optimization. This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives, which can serve as a reference for synthesizing new flavonoid derivatives.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Pharmacology
/
Plants, Medicinal
/
Structure-Activity Relationship
/
Vasodilator Agents
/
Flavonoids
/
Chemistry
/
Antisepsis
/
Fibrinolytic Agents
/
Anti-Inflammatory Agents
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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