Multidrug resistance-associated proteins and their roles in multidrug resistance / 药学学报
Acta Pharmaceutica Sinica
;
(12): 479-486, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-348931
ABSTRACT
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Multidrug resistance-associated proteins (MRPs) play an important role in the process of MDR. As an ATP-binding cassette (ABC) transporter superfamily, MRPs are selective and specific drug efflux pumps. In this paper, physiological characteristics, structural characteristics and resistance profile of MRPs and the associated reversal studies are reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Chemistry
/
Drug Resistance, Multiple
/
Drug Resistance, Neoplasm
/
Multidrug Resistance-Associated Proteins
/
Drug Therapy
/
Metabolism
/
Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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