The transporters of intestinal tract and their study methods / 药学学报
Acta Pharmaceutica Sinica
;
(12): 370-376, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-348946
ABSTRACT
The absorption of oral drug in the intestine is an important factor to determine the drug bioavailability. There are many intestinal transporters mediating drug absorption, distribution, excretion and drug-drug interaction. Understanding the transport mechanism can improve the effectiveness and safety of drug and guide clinical rational use of drugs. The in vivo and in vitro methods are used to predict the transport mechanism of drugs by intestinal transporters in the intestine. The purposes of this article are to introduce the main transporters in the intestinal tract, to explain the transport mechanism and to summarize the advantages and disadvantages of the research methods of them.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Membrane Transport Proteins
/
Biological Availability
/
ATP-Binding Cassette Transporters
/
Anion Transport Proteins
/
Symporters
/
Peptide Transporter 1
/
Intestinal Absorption
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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