Existing problems and strategies in liposome-mediated nucleic acid delivery / 药学学报
Acta Pharmaceutica Sinica
;
(12): 261-268, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-348967
ABSTRACT
Liposome-mediated nucleic acid delivery has been a focus recently, but in the course of delivering nucleic acid, some hurdles seriously limit the nucleic acid exerting treatment effect. This review refers to a series of problems such as low blood stability, reticuloendothelial system absorption, the lower targeting of liposome and the restriction of endosomal escape which are suffered in liposome-mediated nucleic acid delivery; and gives a detail introduction of strategies such as PEGylation, ligand modification, photochemical internalization, the application of degradation liposome and membrane-lytic peptide, to overcome those problems.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyethylene Glycols
/
Polymers
/
Mononuclear Phagocyte System
/
Pharmacokinetics
/
Nucleic Acids
/
Chemistry
/
Nanoparticles
/
Photochemical Processes
/
Liposomes
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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