Association of the neprilysin and apolipoprotein E gene polymorphisms with Alzheimer's disease in Xinjiang Uygur population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 176-179, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-349017
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association between the neprilysin (NEP) gene and apolipoprotein E (ApoE) gene polymorphisms and sporadic Alzheimer's disease (SAD) in Xinjiang Uygur population.</p><p><b>METHODS</b>The polymorphisms of the NEP and ApoE gene were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 111 SAD patients and 117 healthy controls.</p><p><b>RESULTS</b>(1) The frequency of the T allele in the NEP gene was significantly higher in the SAD patients than that in the controls (Chi-square= 5.005, P< 0.05); and there was higher risk to develop SAD in the T allele carriers. (2) The frequency of the ApoE 4 epsilon 4 allele was higher in the SAD patients than in the controls (Chi-square= 4.218, P< 0.05); and the ApoE 4 epsilon 4 carriers had significantly increased risk of developing SAD. (3) No significant interaction was found between the NEP and ApoE polymorphisms in SAD patients.</p><p><b>CONCLUSION</b>The NEP and ApoE gene polymorphisms may be associated with SAD. NEP gene may be an independent genetic risk factor for SAD in Xinjiang Uygur population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins E
/
Neprilysin
/
Ethnicity
/
Case-Control Studies
/
China
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Asian People
/
Ethnology
/
Alzheimer Disease
Type of study:
Observational study
/
Risk factors
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2010
Type:
Article
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