Association of the D358A polymorphism of IL6R gene with type 2 diabetes in Hubei Han Chinese / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 452-456, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-349055
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the D358A polymorphism of interleukin 6 receptor( IL6R ) gene with type 2 diabetes mellitus (T2DM) in Hubei Han Chinese.</p><p><b>METHODS</b>The single nucleotide polymorphism D358A of the IL6R gene was genotyped in 581 T2DM patients and 353 healthy controls. Meta-analysis was used to assess the reported association between the IL6R D358A and T2DM.</p><p><b>RESULTS</b>The frequencies of CC genotype and C allele of IL6R D358A in the patients were significantly lower than those in controls (CC 13.4% vs. 20.7%, P=0.003; C 36.0% vs. 41.8%, P=0.012), with the CC genotype being a protective factor for T2DM (OR=0.595, P=0.003). Logistic regression analysis suggested that the CC genotype was significantly associated with T2DM after adjusted for age, sex, blood pressure and obesity (OR=0.615, 95% CI 0.407- 0.928, P=0.021). Meta-analysis of 6 studies indicated that there existed genetic heterogeneity, and the CC genotype was associated with lower risk of T2DM (P=0.009, OR=0.64, 95% CI 0.48-0.85).</p><p><b>CONCLUSION</b>IL6R is a susceptibility gene for T2DM in Han Chinese population of Hubei, and the CC genotype may serve as a genetic protective factor of T2DM.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Receptors, Interleukin-6
/
Polymorphism, Single Nucleotide
/
Asian People
/
White People
/
Diabetes Mellitus, Type 2
/
Ethnology
/
Genome-Wide Association Study
/
Genetics
/
Genotype
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2009
Type:
Article
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