Association of cytotoxic T lymphocyte antigen-4 promoter C-658T polymorphism with ulcerative colitis in Chinese / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 431-434, 2009.
Article
in Zh
| WPRIM
| ID: wpr-349060
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of gene polymorphism of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) with ulcerative colitis (UC) in Chinese.</p><p><b>METHODS</b>One hundred and seventeen patients with UC and 246 healthy controls were genotyped for the polymorphisms of C-658T in the promoter and C61T at the 3' untranslated region of the CTLA-4 gene using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP), respectively. The genotype and allele frequencies of the two groups were calculated and compared by chi square test.</p><p><b>RESULTS</b>The frequency of TT+CT genotype at the CTLA-4 gene C-658T in the promoter was significantly higher in UC patients than that in healthy controls (P=0.015). The frequency of the T allele at this locus was also significantly higher in UC patients than that in the controls (P=0.033). The frequencies of TT genotype and T allele at the C-658T locus were highly associated with extensive colitis in UC patients (P=0.037, and P=0.0067, respectively).</p><p><b>CONCLUSION</b>The T allele of CTLA-4 promoter C-658T locus was highly associated with UC in Chinese Han of central China.</p>
Full text:
1
Index:
WPRIM
Main subject:
Molecular Sequence Data
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Base Sequence
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Colitis, Ulcerative
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Antigens, CD
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Case-Control Studies
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China
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Promoter Regions, Genetic
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Polymorphism, Single Nucleotide
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Asian People
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Genetic Association Studies
Type of study:
Observational_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2009
Type:
Article