Noninvasive prenatal diagnosis of single gene disorders through cell-free fetal DNA in maternal blood / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 410-413, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-349065
ABSTRACT
The discovery of cell-free fetal DNA (cff-DNA) in maternal plasma offered a new way to noninvasive prenatal diagnosis for single gene disorders. In the past decade, many techniques such as real-time PCR, pyrophosphorolysis-activated polymerization, mass spectrum and digital PCR have been developed for noninvasive prenatal diagnosis. In this review, the author discuss the principles, applications, advantages and disadvantages of these techniques.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prenatal Diagnosis
/
Blood
/
DNA
/
Diagnosis
/
Fetal Diseases
/
Genetics
/
Genetic Diseases, Inborn
/
Maternal-Fetal Exchange
/
Methods
Type of study:
Diagnostic study
Limits:
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2009
Type:
Article
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