Association of serotonin and norepinephrine transporter gene polymorphisms with the susceptibility to depression / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 388-392, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-349069
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether the serotonin transporter (5-HTT) and norepinephrine transporter (NET) gene polymorphisms were associated with the susceptibility to depression.</p><p><b>METHODS</b>Five hundred and seventy-nine patients with depression, evaluated using a 17-item Hamilton Depression Rating Scale for Depression (HAMD), and 437 healthy controls, all of Chinese Han origin, were genotyped by polymerase chain reaction.</p><p><b>RESULTS</b>Both genotype distributions (P=0.033) and allele frequencies (P=0.023, OR = 1.250, 95% CI = 1.031-1.517) of NET-T182C were significantly different between patients and controls, where the T allele was associated with the onset of depression. Both NET-T182C T- and 5- HTTLPR L-carriers had higher baseline HAMD scores (P=0.032 and 0.023, respectively). There was an interaction between NET-T182C and 5-HTTLPR, where the combined genotype distributions were associated with both onset of depression (P=0.006) and the baseline HAMD scores (P=0.007).</p><p><b>CONCLUSION</b>This study suggested a positive relationship between the NET-T182C polymorphism and the susceptibility to depression, and a positive relationship between NET-T182C/5-HTTLPR polymorphisms and the severity of depression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Case-Control Studies
/
Depression
/
Disease Susceptibility
/
Norepinephrine Plasma Membrane Transport Proteins
/
Serotonin Plasma Membrane Transport Proteins
/
Genetic Association Studies
/
Genetics
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2009
Type:
Article
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