The prognostic value of cellular immunity function in patients with hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 194-197, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-349170
ABSTRACT
<p><b>OBJECTIVES</b>To study the changes of cellular immunity function in patients with hepatocellular carcinoma (HCC) and its correlation with disease severity.</p><p><b>METHODS</b>T lymphocyte subsets and CD28 co-stimulation molecule in CD8+ T cells in 22 HCC patients were detected using three-color flow cytometry. Serum interleukin-2 (IL-2), transforming growth factor beta 1 (TGFbeta1), and interleukin-6 (IL-6) were determined by ELISA and radioimmunoassay. A group of 30 patients with chronic hepatitis B (CHB), liver cirrhosis (LC), or normal adults (NC) served as controls.</p><p><b>RESULTS</b>Compared with NC, the number of CD8+CD28- T cells increased and CD8+CD28+ T cells decreased in patients with HCC. The number of CD4+ T cells, CD4+/CD8+ ratios, IL-2 level all decreased and CD8+ T cells, IL-6, TGFbeta1 levels all increased in patients with HCC, LC and CHB. The CD4+ T cells, CD4+/CD8+ ratios and IL-2 level in patients with HCC were lower than those with CHB. Serum IL-6 and TGFbeta1 in patients with HCC were higher than those with LC and CHB. The levels of IL-6 and TGFbeta1 correlated with the stages of the tumors.</p><p><b>CONCLUSIONS</b>HCC patients have a cellular immunity dysfunction. Rectifying the imbalanced function could be a potential way for treating HCC. Measurement of these factors would be useful for early diagnosis and evaluating the prognoses of these patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
T-Lymphocyte Subsets
/
CD4-CD8 Ratio
/
CD28 Antigens
/
Carcinoma, Hepatocellular
/
CD8-Positive T-Lymphocytes
/
Allergy and Immunology
/
Immunity, Cellular
/
Liver Neoplasms
Type of study:
Prognostic study
/
Screening study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2005
Type:
Article
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