Alteration of the content of minor elements in apoptotic cells induced by anti-cancer drugs with synchronous radiation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 265-268, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-349379
ABSTRACT
OBJECTIVE:
To explore the change of content of minor elements and its biological implication in apoptotic processes.METHODS:
The content of minor elements of apoptotic cells from breast cancer induced by anti-cancer drugs was quantitatively analysed with synchronous radiation X-ray fluorescence.RESULTS:
Seven kinds of minor elements including Ti, Cr, Fe, Cu, Zn, Ga and Ge as well as five major elements P, S, Ca, Cl and K were detected in the apoptotic and control cells. The content of elements Zn and P in apoptotic cells after 48 h treatment with taxol and colchicine was significantly increased higher than that in the control cells P<0.05). The content of element Fe in 48 h treatment with taxol was significantly decreased lower than that in the control cells P<0.05). The same trend of change of elements was observed during the process of apoptotic cells death induced with VP-16 or cycloheximide.CONCLUSION:
This results suggest that the elements Zn, Fe and P should be involved in apoptosis induced by anti-cancer drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2002
Type:
Article
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