intercellular adhesion molecule-1 and CD11a/CD18 expression in coronary heart disease / 浙江大学学报·医学版

ABSTRACT

OBJECTIVE: To investigate the expression of soluble intercellular adhesion molecule-1(sICAM-1) and CD11a/CD18 in coronary heart disease(CHD). METHODS: The sICAM-1 and CD11a/CD18 levels were measured by ELISA and flow cytlemetry in 76 CHD patients and 65 healthy subjects. RESULTS: The level of sICAM-1 and CD11a/CD18 were significantly higher in CHD patients than healthy subjects [SICAM-1(g/L)263.5 +/-66.2 compared with 205.9 +/-57.2, P<0.01; CD11a/CD18 (%)33.7 +/-6.4 compared with 19.3 +/-8.1, P<0.001]. They were also significantly higher in acute myocardial infarct and unstable angina than that of stable angina patients. There was correlation between sICAM-1 and CD11a/CD18(r=0.436, P<0.01). CONCLUSION: Elevated levels of sICAM-1 and CD11a/CD18 associated with unstable angina and myocardial infarction may indicate their significant role in the pathogenesis of acute coronary events.