Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy / 癌症
Chinese Journal of Cancer
;
(12): 541-553, 2015.
Article
in English
| WPRIM
| ID: wpr-349573
ABSTRACT
Stem cells are known to maintain stemness at least in part through secreted factors that promote stem-like phenotypes in resident cells. Accumulating evidence has clarified that stem cells release nano-vesicles, known as exosomes, which may serve as mediators of cell-to-cell communication and may potentially transmit stem cell phenotypes to recipient cells, facilitating stem cell maintenance, differentiation, self-renewal, and repair. It has become apparent that stem cell-derived exosomes mediate interactions among stromal elements, promote genetic instability in recipient cells, and induce malignant transformation. This review will therefore discuss the potential of stem cell-derived exosomes in the context of stromal remodeling and their ability to generate cancer-initiating cells in a tumor niche by inducing morphologic and functional differentiation of fibroblasts into tumor-initiating fibroblasts. In addition, the immunosuppressive potential of stem cell-derived exosomes in cancer immunotherapy and their prospective applications in cell-free therapies in future translational medicine is discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Therapeutics
/
Neoplastic Stem Cells
/
Organelle Biogenesis
/
Cell Communication
/
Cell Transformation, Neoplastic
/
Apoptosis
/
Disease Progression
/
Exosomes
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS