miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis / 癌症
Chinese Journal of Cancer
;
(12): 485-487, 2015.
Article
in English
| WPRIM
| ID: wpr-349575
ABSTRACT
Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem affecting prognosis. Our recent study established that microRNA-506 (miR-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that miR-506 could augment the response to cisplatin and olaparib through targeting RAD51 and suppressing homologous recombination in a panel of ovarian cancer cell lines. Systemic delivery of miR-506 in an orthotopic ovarian cancer mouse model significantly augmented the cisplatin response, thus recapitulating the clinical observation. Therefore, miR-506 plays a functionally important role in homologous recombination and has important therapeutic value for sensitizing cancer cells to chemotherapy, especially in chemo-resistant patients with attenuated expression of miR-506.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Piperazines
/
Prognosis
/
Cisplatin
/
Disease-Free Survival
/
Drug Resistance, Neoplasm
/
MicroRNAs
/
Cell Line, Tumor
/
Drug Therapy, Combination
/
Rad51 Recombinase
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2015
Type:
Article
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