Epstein-Barr virus and the origin of Hodgkin lymphoma / 癌症
Chinese Journal of Cancer
;
(12): 591-597, 2014.
Article
in English
| WPRIM
| ID: wpr-349625
ABSTRACT
Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Hodgkin Disease
/
Reed-Sternberg Cells
/
Herpesvirus 4, Human
/
Epstein-Barr Virus Infections
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS